Thymagen Reconstitution Calculator
Enter the amount you want to measure. The vial buttons will highlight which vial strengths create cleaner syringe-unit measurements.
What amount do you need?
Type the target amount, then choose mg or mcg. Example: 2mg or 500mcg.
Syringe size:
Possible vial strengths:
Best Match
Good Match
Usable
Harder to Measure
Example Thymagen Titration Schedule
| Phase | Timeframe | Schedule (As Listed) |
|---|---|---|
| Loading | Year 1 — Month 1 | Daily |
| Loading | Year 1 — Months 2–3 | Daily for 10–20 days at the start of each month |
| Loading | Year 1 — Months 4–12 | Off |
| Maintenance | Year 2+ | 10–20 day cycles, 3× per year spread out evenly |
Possible vial strengths:
What Is It?
Thymagen
Short peptide studied for thymic signaling.
Bacteriostatic Water
Sterile water containing a bacteriostatic preservative, commonly used when preparing multi-use research vials.
How To Mix Thymagen
1
CleanUse alcohol swabs to clean the tops of both vials.
2
Draw BAC WaterDraw the selected amount of bacteriostatic water.
3
Inject SlowlyAdd the liquid slowly down the side of the vial.
4
Swirl GentlyDo not shake. Swirl gently until dissolved.
5
Store ProperlyStore as directed and protect from heat and light.
Best Practices & Common Mistakes
Best Practices
- Use sterile technique.
- Protect from light and heat.
- Store refrigerated when appropriate.
- Use clean syringe-unit math before measuring.
Common Mistakes
- Confusing milligrams with milliliters.
- Choosing an option with awkward decimal units.
- Using too little liquid for very small measurements.
- Shaking the vial aggressively.
Thymagen Storage & Handling
Lyophilized Powder: −20°C (−4°F) for long-term storage (up to 24 months). Refrigeration 2–8°C (36–46°F) for short-term use (up to ~3 months). Original sealed vial in the freezer is safest.
Reconstituted Solution: 2–8°C (36–46°F), use within ~7–14 days. Keep sealed, avoid light, and do not repeat freeze-thaw cycles.
Reconstituted Solution: 2–8°C (36–46°F), use within ~7–14 days. Keep sealed, avoid light, and do not repeat freeze-thaw cycles.
Frequently Asked Questions
The calculator treats pharmacokinetics as linear. In reality, the terminal half‑life of the dipeptide is no more than 60 minutes (range 27‑60 min) [17†L20-L21]. This rapid clearance is fine because the biological activity is not dependent on continuous presence—the peptide triggers a sequence of events that lead to a long‑lasting immunocorrecting effect [21†L16-L19]. The same short plasma lifetime allows the product to be approved and used effectively in clinical protocols lasting 10 days [16†L11-L12].
A fixed ratio of 20 mg : 5 mL yields a concentration of 4 mg/mL [15†L17-L18]. The vials for intranasal administration, where the treatment is one puff of 25 µg in each nostril twice a day for 10 days, are sold as 10 mL (containing 250 µg/mL) [17†L10-L11]. Using a different volume would break the dosage protocol (0.1 mL = 25 µg) on which the approved drug's safety and efficacy are based.
What is used for immune stimulation is the L‑Glu‑L‑Trp dipeptide (Thymogen) [7†L20-L21]. Its enantiomer, Thymodepressin, is composed of D‑Glu(D‑Trp) and acts as an immunosuppressor [7†L20-L21]. The calculator cannot inspect the vial; the responsibility is on the user to confirm that the CAS number and Certificate of Analysis correspond to the L‑form (e.g., 38101‑59‑6) for immune stimulation.
In a recent rodent study, the effect at 10 µg/kg was comparable to that at 100 µg/kg (and 100 µg/kg was not superior to 10 µg/kg), indicating a saturable effect where a low dose is already enough [13†L6-L9]. The calculator will mechanically increase the syringe volume if you enter a higher mg value, but doing so is biologically unnecessary.
The powder is stable for up to 28 days at 2‑8 °C in aqueous solution under sterile conditions [8†L45-L46]. If you keep the vial in the fridge (2‑8 °C), prevent contamination (sterile technique, alcohol wipes), and avoid leaving the vial at room temperature for hours, the solution should remain potent over the 28‑day period. Your calculator can treat the 20 mg vial as providing 28 daily doses of ~0.7 mg each, and the preparation will maintain its activity for the full 4‑week protocol.
Practical takeaway: If your real goal is weight or metabolic health, the most useful next step is discussing approved treatment options with a clinician rather than relying on an unapproved compound.
Important: This tool is for informational and research-reference purposes only. Not intended for human or veterinary use.