Lotiglipron Reconstitution Calculator
Enter the amount you want to measure. The vial buttons will highlight which vial strengths create cleaner syringe-unit measurements.
What amount do you need?
Type the target amount, then choose mg or mcg. Example: 2mg or 500mcg.
Syringe size:
Possible vial strengths:
Best Match
Good Match
Usable
Harder to Measure
Example Lotiglipron Titration Schedule
| Parameter | Details |
|---|---|
| Dosage | Up to 180 mg/day (target doses 10–180 mg/day) |
| Route | Oral (once‑daily tablet) |
| Frequency | Once daily |
| Cycle Length | 28–42 days (Phase 1 trials) |
| Half‑life | Not established (PK profile supports once‑daily dosing) |
| Reconstitution | Not applicable (oral formulation) |
Possible vial strengths:
What Is It?
Lotiglipron
Oral non-peptide GLP-1 receptor agonist.
Bacteriostatic Water
Sterile water containing a bacteriostatic preservative, commonly used when preparing multi-use research vials.
How To Mix Lotiglipron
1
CleanUse alcohol swabs to clean the tops of both vials.
2
Draw BAC WaterDraw the selected amount of bacteriostatic water.
3
Inject SlowlyAdd the liquid slowly down the side of the vial.
4
Swirl GentlyDo not shake. Swirl gently until dissolved.
5
Store ProperlyStore as directed and protect from heat and light.
Best Practices & Common Mistakes
Best Practices
- Use sterile technique.
- Protect from light and heat.
- Store refrigerated when appropriate.
- Use clean syringe-unit math before measuring.
Common Mistakes
- Confusing milligrams with milliliters.
- Choosing an option with awkward decimal units.
- Using too little liquid for very small measurements.
- Shaking the vial aggressively.
Lotiglipron Storage & Handling
Lyophilized Powder: −20°C (−4°F) for long-term storage (up to 24 months). Refrigeration 2–8°C (36–46°F) for short-term use (up to ~3 months). Original sealed vial in the freezer is safest.
Reconstituted Solution: 2–8°C (36–46°F), use within ~7–14 days. Keep sealed, avoid light, and do not repeat freeze-thaw cycles.
Reconstituted Solution: 2–8°C (36–46°F), use within ~7–14 days. Keep sealed, avoid light, and do not repeat freeze-thaw cycles.
Frequently Asked Questions
Lotiglipron was an oral, non‑peptide small‑molecule GLP‑1R agonist. It was not developed for injection; the entire clinical program was based on once‑daily oral dosing with no fasting requirements. Your peptide calculator is designed for reconstitution and injection — it has no application here.
Water: insoluble. Unlike water‑soluble peptides, lotiglipron requires anhydrous DMSO for dissolution (100‑125 mg/mL) with ultrasonication. For an oral suspension (the intended research route), the validated vehicle is CMC‑Na at ≥5 mg/mL. Do not use BAC water.
The dry powder is stable for 3 years at –20 °C and 2 years at 4 °C. Once dissolved in an organic solvent (e.g., DMSO), the solution must be stored at –80 °C for 6 months or at –20 °C for 1 month. The solution should be used immediately after preparation — repeated freeze‑thaw cycles will degrade the compound.
Your calculator is designed for peptide‑scale microgram doses. Lotiglipron is a small molecule dosed in the milligram range. Phase 1 multiple‑ascending‑dose studies used target doses from 10 mg up to 180 mg per day. The highest tested dose was 180 mg. Entering microgram amounts will produce no effect.
Small molecules carry safety liabilities that peptides often avoid. Pfizer terminated lotiglipron development in June 2023 after early‑stage trials showed elevated liver enzymes (transaminases), indicating potential liver toxicity. There were no pre‑clinical alerts for hepatotoxicity. Your calculator cannot predict this. Always monitor liver enzyme levels in small‑molecule studies, regardless of what the dilution math suggests
Practical takeaway: If your real goal is weight or metabolic health, the most useful next step is discussing approved treatment options with a clinician rather than relying on an unapproved compound.
Important: This tool is for informational and research-reference purposes only. Not intended for human or veterinary use.